Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL956736 | 0.77 | CHRNB4 (0.41) | CHRNB4CHRNA3KDM1AKDM1BCHRNB2 | |
| SCHEMBL18544377 | 0.74 | CHRNB4 (0.43) | CHRNB4CHRNA3KDM1AKDM1BCA2 | |
| SCHEMBL5704636 | 0.73 | KDM1A (0.57) | KDM1AKDM1B | |
| SCHEMBL10486425 | 0.73 | CHRNB4 (0.41) | CHRNB4CHRNA3KDM1AKDM1BCHRNB2 | |
| SCHEMBL7329321 | 0.73 | KDM1A (0.57) | KDM1AKDM1B | |
| SCHEMBL6928599 | 0.73 | CHRNB4 (0.41) | CHRNB4CHRNA3KDM1AKDM1BCHRNB2 | |
| SCHEMBL14284253 | 0.73 | KDM1A (0.57) | KDM1AKDM1B | |
| SCHEMBL7329314 | 0.73 | KDM1A (0.57) | KDM1AKDM1B | |
| SCHEMBL5341308 | 0.73 | KDM1A (0.57) | KDM1AKDM1B | |
| SCHEMBL9442858 | 0.72 | CHRNB4 (0.38) | CHRNB4CHRNA3KDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459145-A | Calcium independent camp phosphodiesterase inhibitor antidepressant | PFIZER INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |