Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24158834 | 0.84 | KMT2A (0.41) | GAAPDE4BITGB3ITGA2BKMT2A | |
| SCHEMBL9387116 | 0.82 | KMT2A (0.32) | GAAKMT2ASMN1; SMN2RENALDH1A1 | |
| SCHEMBL3435947 | 0.81 | GAA (0.47) | GAAITGB3ITGA2BNOS3NOS2 | |
| SCHEMBL9835380 | 0.81 | NPC1 (0.46) | CHRM1KMT2A | |
| SCHEMBL10140462 | 0.79 | ITGB3 (0.34) | GAAITGB3ITGA2BCHRM1 | |
| SCHEMBL356124 | 0.79 | ITGB3 (0.34) | GAAITGB3ITGA2BCHRM1 | |
| SCHEMBL1700940 | 0.79 | KMT2A (0.40) | GAAPDE4BNOS3NOS2KMT2A | |
| SCHEMBL23581416 | 0.79 | GAA (0.41) | GAAITGB3ITGA2BNOS3NOS2 | |
| SCHEMBL9442983 | 0.78 | REN (0.38) | ITGB3ITGA2BKMT2ARENALDH1A1 | |
| SCHEMBL9442985 | 0.78 | REN (0.38) | ITGB3ITGA2BKMT2ARENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0543936-A4 | RENIN INHIBITORS | — | 1993-06-30 | — | — | EP | disclosed |
| EP-0543936-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |