Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419297 | 0.82 | KIF11 (0.58) | KIF11PARP1RAB9ADYRK1AALOX15 | |
| SCHEMBL7368864 | 0.81 | KIF11 (0.61) | KIF11PARP1RAB9ADYRK1AALOX15 | |
| SCHEMBL25207025 | 0.78 | ALOX15 (0.57) | RAB9AALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29708168 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL4725998 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL22346720 | 0.77 | ALOX15 (0.53) | KIF11ALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4877545 | 0.77 | KDM4E (0.67) | RAB9AALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29955715 | 0.77 | ALOX15 (0.74) | ALOX15ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7419884 | 0.76 | KIF11 (0.58) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL19954219 | 0.76 | KIF11 (0.49) | KIF11PARP1RAB9ADYRK1AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192132-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000076971-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |