Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666303 | 0.91 | CTSL (0.43) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7661378 | 0.90 | CCNE1 (0.51) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7358873 | 0.90 | CTSL (0.46) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7672696 | 0.89 | CTSL (0.42) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7671239 | 0.89 | PDGFRA (0.43) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7667689 | 0.89 | KCNH3 (0.46) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7672206 | 0.88 | CTSL (0.44) | CTSLCDK1KCNH3PDGFRACCNE1 | |
| SCHEMBL7661510 | 0.87 | PDGFRA (0.41) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7365457 | 0.87 | PDGFRA (0.39) | CTSLPDGFRACCNE1CDK2BTK | |
| SCHEMBL7672226 | 0.83 | CDK1 (0.45) | CTSLCDK1KCNH3PDGFRACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |
| WO-2000037471-A1 | 2-AMINO-9-ALKYLPURINES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |