Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737444 | 0.91 | MAPT (0.55) | ALDH1A1KDM4EKMT2AHRH3MAPT | |
| Trifluoroacetic Acid SCHEMBL735794 | 0.86 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AHRH3MAPT | |
| SCHEMBL738382 | 0.84 | HRH3 (0.53) | ALDH1A1KMT2AHRH3MAPTKCNH2 | |
| SCHEMBL736505 | 0.84 | HRH3 (0.48) | ALDH1A1HRH3MAPTKCNH2MET | |
| Trifluoroacetic Acid SCHEMBL737443 | 0.78 | HRH3 (0.60) | ALDH1A1KDM4EKMT2AHRH3MAPT | |
| Trifluoroacetic Acid SCHEMBL736519 | 0.77 | HRH3 (0.55) | ALDH1A1KDM4EHRH3MAPTPOLB | |
| Trifluoroacetic Acid SCHEMBL735635 | 0.77 | HRH3 (0.57) | ALDH1A1KDM4EHRH3MAPTPOLB | |
| Trifluoroacetic Acid SCHEMBL737476 | 0.75 | HRH3 (0.55) | ALDH1A1KDM4EKMT2AHRH3MAPT | |
| Trifluoroacetic Acid SCHEMBL737095 | 0.75 | HRH3 (0.55) | ALDH1A1KDM4EKMT2AHRH3MAPT | |
| SCHEMBL13437995 | 0.74 | DRD2 (0.69) | ALDH1A1KDM4EKMT2AHRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | claimed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | claimed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | claimed |
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | ALDH1A1 1242/4885KDM4E 1039/4885KMT2A 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.