Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358341 | 0.87 | SIGMAR1 (0.49) | ANPEPERAP2SIGMAR1ADRB2TRPA1 | |
| SCHEMBL7286461 | 0.85 | SIGMAR1 (0.46) | ANPEPERAP2SIGMAR1ADRB2KCNH2 | |
| SCHEMBL7296276 | 0.83 | BCHE (0.50) | ANPEP | |
| SCHEMBL31122408 | 0.80 | ADRB2 (0.53) | ANPEPERAP2SIGMAR1ADRB2KCNH2 | |
| SCHEMBL7288361 | 0.78 | CYP1A2 (0.56) | ADRB2ADRB1ADRB3 | |
| SCHEMBL7483127 | 0.77 | ADRB2 (0.50) | ANPEPERAP2SIGMAR1ADRB2KCNH2 | |
| SCHEMBL10614261 | 0.77 | FFAR4 (0.50) | SIGMAR1ADRB2KCNH2ADRB1ADRB3 | |
| SCHEMBL27742458 | 0.76 | MAPT (0.58) | SIGMAR1TRPA1TRPV1 | |
| SCHEMBL7287523 | 0.76 | KDM4E (0.62) | ADRB2KMT2A | |
| SCHEMBL1022227 | 0.74 | ADRB2 (0.54) | ANPEPERAP2SIGMAR1ADRB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |