SCHEMBL7359106

SCHEMBL7359106

CC(C)(C)OC(=O)Cc1cc[nH]c(=O)c1N

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 5/20 0.39
MTNR1B P49286 5/20 0.39
MAPT P10636 4/20 0.36
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
JAK1 P23458 2/20 0.32
JAK2 O60674 1/20 0.32
JAK3 P52333 1/20 0.32
POLB P06746 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27340187 0.78 RAB9A (0.45) MTNR1AMTNR1BMAPTRAB9ANPC1
SCHEMBL1870727 0.76 MAPT (0.44) MAPTPOLBL3MBTL1KMT2ATDP1
SCHEMBL7352775 0.75 MTNR1A (0.39) MTNR1AMTNR1BMAPTSMN1; SMN2KMT2A
SCHEMBL16410214 0.73 MTNR1A (0.44) MTNR1AMTNR1BSMN1; SMN2L3MBTL1
SCHEMBL7351782 0.72 MTNR1A (0.37) MTNR1AMTNR1B
SCHEMBL16410217 0.72 MTNR1A (0.43) MTNR1AMTNR1BPOLBKMT2A
SCHEMBL16410283 0.72 MTNR1A (0.47) MTNR1AMTNR1BALDH1A1
SCHEMBL16410270 0.72 MTNR1A (0.47) MTNR1AMTNR1BRAB9ANPC1L3MBTL1
SCHEMBL29805519 0.72 MTNR1A (0.47) MTNR1AMTNR1BALDH1A1
SCHEMBL16410344 0.71 MTNR1A (0.51) MTNR1AMTNR1BSMN1; SMN2L3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036063-A1 HETEROARYL AMINOGUANIDINES AND ALKOXYGUANIDINES AND THEIR USE AS PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-09-20 EP disclosed
WO-1999026926-A1 HETEROARYL AMINOGUANIDINES AND ALKOXYGUANIDINES AND THEIR USE AS PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1999-06-03 WO disclosed