SCHEMBL7359295

SCHEMBL7359295

CCC(C)[C@H](N)C(=O)C(N)c1ccccn1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP8 Q6V1X1 3/20 0.45
DPP9 Q86TI2 3/20 0.45
ALDH1A1 P00352 4/20 0.44
CYP1A2 P05177 2/20 0.44
DPP7 Q9UHL4 2/20 0.43
DPP4 P27487 1/20 0.43
CYP3A4 P08684 2/20 0.42
MEN1 O00255 1/20 0.42
GAA P10253 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KCNA5 P22460 3/20 0.39
KCNH2 Q12809 1/20 0.39
KDM4E B2RXH2 3/20 0.38
MAPT P10636 2/20 0.38
POLB P06746 1/20 0.37
CYP2C19 P33261 1/20 0.37
TSHR P16473 2/20 0.37
CYP2D6 P10635 1/20 0.37
KCNE1 P15382 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7359301 1.00 DPP8 (0.45) DPP8DPP9ALDH1A1CYP1A2DPP7
SCHEMBL28187292 0.81 DPP8 (0.46) DPP8DPP9ALDH1A1DPP7DPP4
SCHEMBL9484211 0.81 CYP1A2 (0.46) ALDH1A1CYP1A2CYP3A4MEN1GAA
SCHEMBL9442961 0.77 CTSD (0.36) DPP8DPP9ALDH1A1CYP1A2DPP7
SCHEMBL9641318 0.76 CTSK (0.39) DPP8DPP9ALDH1A1CYP1A2SMN1; SMN2
SCHEMBL9641106 0.76 CTSK (0.39) DPP8DPP9ALDH1A1CYP1A2SMN1; SMN2
SCHEMBL3890657 0.75 POLB (0.57) ALDH1A1GAASMN1; SMN2KDM4EPOLB
SCHEMBL16151826 0.74 CYP3A4 (0.47) ALDH1A1CYP1A2CYP3A4MEN1GAA
SCHEMBL16204245 0.74 CYP3A4 (0.47) ALDH1A1CYP1A2CYP3A4MEN1GAA
SCHEMBL3243742 0.74 SMN1; SMN2 (0.62) ALDH1A1CYP1A2CYP3A4MEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0578745-A1 PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES THE UPJOHN COMPANY (US) 1994-01-19 EP disclosed
WO-1992017490-A1 PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES THE UPJOHN COMPANY (US) 1992-10-15 WO disclosed