Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 9/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359356 | 1.00 | SERPINE1 (0.70) | SERPINE1HTR1AHTR2AHTR7PIM1 | |
| SCHEMBL7354523 | 0.84 | SERPINE1 (0.72) | SERPINE1HTR7KDM4E | |
| SCHEMBL7354535 | 0.84 | SERPINE1 (0.72) | SERPINE1HTR7KDM4E | |
| SCHEMBL7360006 | 0.83 | SERPINE1 (0.77) | SERPINE1PIM1KDM4EMAPT | |
| SCHEMBL7360011 | 0.83 | SERPINE1 (0.77) | SERPINE1PIM1KDM4EMAPT | |
| SCHEMBL7359291 | 0.82 | SERPINE1 (1.00) | SERPINE1HTR1AHTR2AHTR7CYP1A2 | |
| SCHEMBL7359303 | 0.82 | SERPINE1 (1.00) | SERPINE1HTR1AHTR2AHTR7CYP1A2 | |
| SCHEMBL7362875 | 0.82 | SERPINE1 (0.72) | SERPINE1HTR1AHTR2AHTR7 | |
| SCHEMBL7362877 | 0.82 | SERPINE1 (0.72) | SERPINE1HTR1AHTR2AHTR7 | |
| SCHEMBL7363228 | 0.80 | SERPINE1 (0.66) | SERPINE1HTR1AHTR2AHTR7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995032190-A2 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-11-30 | — | — | WO | claimed |
| US-5750530-A | PLASMINOGEN ACTIVATOR INHIBITORS | XENOVA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| WO-1995032190-A2 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-11-30 | — | — | WO | disclosed |