SCHEMBL7359688

SCHEMBL7359688

CC1(CN)CNc2nc(N)[nH]c(=O)c2N1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 9/20 0.48
NOS3 P29474 2/20 0.44
NOS2 P35228 2/20 0.44
CASP7 P55210 2/20 0.40
HSD17B10 Q99714 2/20 0.40
USP2 O75604 1/20 0.40
KDM4E B2RXH2 2/20 0.40
MAPT P10636 2/20 0.40
BLM P54132 2/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 1/20 0.40
GLA P06280 1/20 0.40
HPGD P15428 1/20 0.40
PMP22 Q01453 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PAH P00439 1/20 0.38
MEN1 O00255 1/20 0.35
RGS12 O14924 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18599011 0.74 NOS1 (0.52) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL20375130 0.69 NOS1 (0.47) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL3800890 0.69 NOS1 (0.38) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL3454164 0.68 NOS1 (0.53) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL2523525 0.68 NOS1 (0.53) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL17556623 0.67 NOS1 (0.49) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL16554109 0.67
Hydrochloric Acid SCHEMBL10803149 0.65 PAH (0.42) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL13912794 0.64 NOS1 (0.35) NOS1NOS3NOS2CASP7HSD17B10
SCHEMBL584982 0.64 NOS1 (0.64) NOS1NOS3NOS2CASP7HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5401844-A Chemical intermediates for treatment of parkinson*s disease SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1995-03-28 US disclosed
US-5196533-A Treatment of Parkinson*s disease, inhibitor of thymidylate synthetase SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION, USA (US) 1993-03-23 US disclosed
EP-0138995-B1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES South Alabama Medical Science Foundation (US) 1991-08-14 EP disclosed
EP-0138995-A4 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. UNIV SOUTH ALABAMA (US) 1988-05-10 EP disclosed
EP-0138995-A1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. UNIV SOUTH ALABAMA (US) 1985-05-02 EP disclosed
WO-1984004040-A1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES UNIV SOUTH ALABAMA (US) 1984-10-25 WO disclosed