Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 10/20 | 0.53 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PAH | P00439 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523525 | 0.84 | NOS1 (0.53) | NOS1NOS3NOS2CASP7HSD17B10 | |
| SCHEMBL26018101 | 0.76 | NOS1 (0.32) | NOS1CASP7HSD17B10USP2MAPT | |
| SCHEMBL12102081 | 0.76 | ALDH1A1 (0.38) | NOS1NOS3NOS2USP2MAPT | |
| SCHEMBL17556623 | 0.76 | NOS1 (0.49) | NOS1NOS3NOS2CASP7HSD17B10 | |
| Acetic Acid SCHEMBL10480604 | 0.75 | NOS1 (0.47) | NOS1NOS3NOS2CASP7HSD17B10 | |
| SCHEMBL10064935 | 0.74 | TYMS (0.41) | NOS1NOS3NOS2PNP | |
| SCHEMBL584982 | 0.72 | NOS1 (0.64) | NOS1NOS3NOS2CASP7HSD17B10 | |
| SCHEMBL29501873 | 0.72 | NOS1 (0.30) | NOS1NOS3NOS2 | |
| SCHEMBL29016448 | 0.72 | TYMS (0.37) | NOS1NOS3NOS2 | |
| SCHEMBL2727252 | 0.72 | LMNA (0.51) | NOS1NOS3NOS2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119925601-A | Application of tetrahydrobiopterin pathway as target in anti-QDPR deletion type tumor | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2025-05-06 | — | — | CN | claimed |
| EP-1116721-B1 | Process for the reduction of pterines | CERBIOS PHARMA SA (CH) | 2003-03-12 | — | — | EP | claimed |
| EP-1116721-A1 | Process for the reduction of pterines | Cerbios-Pharma S.A. (CH) | 2001-07-18 | — | — | EP | claimed |
| US-6162914-A | Process for the reduction of pterins | CERBIOS-PHARMA S.A. (CH) | 2000-12-19 | — | — | US | claimed |
| JP-7188232-A | — | — | None | — | — | JP | disclosed |
| CN-120060106-A | Genetically engineered bacterium and method for producing 5-hydroxytryptophan by whole cell catalysis | 山西师范大学 | 2025-05-30 | — | — | CN | disclosed |
| CN-119925601-A | Application of tetrahydrobiopterin pathway as target in anti-QDPR deletion type tumor | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2025-05-06 | — | — | CN | disclosed |
| CN-118460586-A | Overexpression vector, cofactor-independent 5-HTP synthetic strain, method and application | 天津科技大学 | 2024-08-09 | — | — | CN | disclosed |
| WO-2023016134-A1 | COMPOUND CONTAINING TETRAHYDROPTERIN STRUCTURE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国药科大学 | 2023-02-16 | — | — | WO | disclosed |
| EP-2162456-B1 | Stable crystalline (6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid, process for its preparation and its use | CERBIOS PHARMA SA (CH) | 2011-07-06 | — | — | EP | disclosed |
| US-7816525-B1 | Process for the preparation of optically pure tetrahydropterins and derivatives, and specifically of optically pure tetrahydrofolic acid and derivatives thereof, by stereospecific hydrogenation | Merck & Cie (CH) | 2010-10-19 | — | — | US | disclosed |
| US-7816525-B1 | Process for the preparation of optically pure tetrahydropterins and derivatives, and specifically of optically pure tetrahydrofolic acid and derivatives thereof, by stereospecific hydrogenation | Merck & Cie (CH) | 2010-10-19 | — | — | US | disclosed |
| EP-1116721-B1 | Process for the reduction of pterines | CERBIOS PHARMA SA (CH) | 2003-03-12 | — | — | EP | disclosed |
| EP-1200437-A1 | METHOD FOR PRODUCING BY STEREOSPECIFIC HYDRATION TETRAHYDROPTERINS AND OPTICALLY PURE DERIVATIVES, IN PARTICULAR TETRAHYDROFOLIC ACID AND ITS OPTICALLY PURE DERIVATIVES | EPROVA AG Forschungsinstitut (CH) | 2002-05-02 | — | — | EP | disclosed |
| EP-1116721-A1 | Process for the reduction of pterines | Cerbios-Pharma S.A. (CH) | 2001-07-18 | — | — | EP | disclosed |
| EP-1116721-A1 | Process for the reduction of pterines | Cerbios-Pharma S.A. (CH) | 2001-07-18 | — | — | EP | disclosed |
| WO-2001004120-A1 | METHOD FOR PRODUCING BY STEREOSPECIFIC HYDRATION TETRAHYDROPTERINS AND OPTICALLY PURE DERIVATIVES, IN PARTICULAR TETRAHYDROFOLIC ACID AND ITS OPTICALLY PURE DERIVATIVES | EPROVA AG (CH) | 2001-01-18 | — | — | WO | disclosed |
| US-6162914-A | Process for the reduction of pterins | CERBIOS-PHARMA S.A. (CH) | 2000-12-19 | — | — | US | disclosed |
| US-6162914-A | Process for the reduction of pterins | CERBIOS-PHARMA S.A. (CH) | 2000-12-19 | — | — | US | disclosed |
| JP-H07188232-A | CELL DAMAGE SUPPRESSING AGENT | ASAHI BREWERIES LTD | 1995-07-25 | — | — | JP | disclosed |