Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790395 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR2CPRCPSLC18A3SLC6A4 | |
| SCHEMBL9531072 | 0.67 | NPC1 (0.47) | SIGMAR1HTR2CSLC6A3 | |
| SCHEMBL531984 | 0.66 | SIGMAR1 (1.00) | SIGMAR1HTR2CHTR7 | |
| SCHEMBL30566630 | 0.66 | SIGMAR1 (0.38) | SIGMAR1HTR2CSLC18A3SLC6A3HTR1A | |
| SCHEMBL4790265 | 0.65 | HTR2C (0.54) | HTR2CSLC6A3 | |
| SCHEMBL3905276 | 0.64 | PTGS1 (0.33) | SIGMAR1HTR2CCYP1A2 | |
| Hydrochloric Acid SCHEMBL652812 | 0.64 | HTR2C (1.00) | SIGMAR1HTR2CHTR7 | |
| SCHEMBL10988298 | 0.64 | SIGMAR1 (0.53) | SIGMAR1HTR2CCYP1A2HTR7 | |
| SCHEMBL28560407 | 0.64 | SIGMAR1 (0.52) | SIGMAR1HTR2CCYP1A2SLC18A3 | |
| SCHEMBL7134932 | 0.64 | SIGMAR1 (0.37) | SIGMAR1HTR2CCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |