Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367836 | 0.88 | IKBKB (0.42) | MAP2K4ALDH1A1CAMKK2HDAC1HDAC6 | |
| SCHEMBL7365557 | 0.84 | MAPT (0.48) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL7364007 | 0.84 | IDO1 (0.48) | MAP2K4KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7368926 | 0.78 | CDK4 (0.47) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7365581 | 0.75 | CDK8 (0.48) | ALDH1A1HPGDNPC1RAB9AGPR84 | |
| SCHEMBL7361974 | 0.73 | NR4A2 (0.36) | KMT2AMEN1 | |
| SCHEMBL4659229 | 0.72 | NAPRT (0.52) | KDM4EALDH1A1KMT2ACAMKK2TTR | |
| SCHEMBL7364174 | 0.71 | KDR (0.46) | MAP2K4KDM4EALDH1A1KMT2ANPC1 | |
| SCHEMBL7366065 | 0.70 | MIF (0.39) | KDM4EALDH1A1GAAKMT2ANPC1 | |
| SCHEMBL1663134 | 0.70 | HDAC1 (0.66) | KDM4EALDH1A1TTRHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |