Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.47 |
| ▸ | CCND1 | P24385 | 9/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370353 | 0.85 | MAOB (0.53) | MAPTSMN1; SMN2MAOBPKMALDH1A1 | |
| SCHEMBL7369411 | 0.84 | RAB9A (0.42) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7364007 | 0.82 | IDO1 (0.48) | NPC1MAPTRAB9ASMN1; SMN2PKM | |
| SCHEMBL7367836 | 0.77 | IKBKB (0.42) | ALDH1A1 | |
| SCHEMBL7365557 | 0.76 | MAPT (0.48) | MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7361974 | 0.75 | NR4A2 (0.36) | IDO1 | |
| SCHEMBL7365581 | 0.75 | CDK8 (0.48) | NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7370627 | 0.73 | MAOB (0.51) | MAOBIDO1KDM4EALDH1A1ADORA1 | |
| SCHEMBL7366344 | 0.72 | MAOB (0.50) | NPC1MAPTRAB9ASMN1; SMN2MAOB | |
| SCHEMBL7364174 | 0.71 | KDR (0.46) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |