Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365581 | 0.88 | CDK8 (0.48) | ALDH1A1HPGDGPR84DHODHKDM5B | |
| SCHEMBL7361974 | 0.83 | NR4A2 (0.36) | IDO1KDRDHODH | |
| SCHEMBL7367836 | 0.83 | IKBKB (0.42) | MAPK1ALDH1A1MAP2K4KDRCAMKK2 | |
| SCHEMBL2396369 | 0.76 | KDM4E (0.51) | IDO1MAPK1ALDH1A1KDM4EPTPRC | |
| SCHEMBL7365409 | 0.73 | ALDH1A1 (0.44) | IDO1MAPK1ALDH1A1KDM4ETDO2 | |
| SCHEMBL24727844 | 0.73 | HDAC1 (0.63) | MAPK1ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL30079151 | 0.68 | CA1 (0.57) | MAPK1ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7091188 | 0.68 | CCNE2 (0.69) | IDO1MAPK1PTPRCPTPRFPTPN1 | |
| SCHEMBL7364174 | 0.68 | KDR (0.46) | MAPK1ALDH1A1KDM4ESMN1; SMN2PTPRC | |
| SCHEMBL2948502 | 0.67 | PIK3CD (0.51) | IDO1MAPK1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |