Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1218407 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL10485411 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL23106949 | 0.85 | ALDH1A1 (0.40) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL7663419 | 0.83 | POLB (0.35) | ALDH1A1TDP1KMT2ARECQLL3MBTL1 | |
| SCHEMBL3781306 | 0.83 | POLB (0.35) | ALDH1A1TDP1KMT2ARECQLL3MBTL1 | |
| SCHEMBL14566116 | 0.80 | ALDH1A1 (0.34) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL1217695 | 0.80 | ALDH1A1 (0.38) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL18906485 | 0.77 | ALDH1A1 (0.32) | ALDH1A1TDP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11721786 | 0.72 | ALDH1A1 (0.38) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL22666980 | 0.72 | ALDH1A1 (0.38) | ALDH1A1TDP1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376539-B1 | ANTIISCHEMIC AGENTS, CENTRAL NERVOUS SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-23 | — | — | US | disclosed |
| EP-1047686-A1 | SUBSTITUTED BICYCLIC LACTONES | Bayer Aktiengesellschaft (DE) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036418-A1 | SUBSTITUTED BICYCLIC LACTONES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | disclosed |