Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364049 | 0.93 | PDE4B (0.52) | PDE4APDE4BPDE4DPDE4CPDE3B | |
| SCHEMBL7356450 | 0.83 | LMNA (0.37) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7365858 | 0.83 | PDE4B (0.51) | PDE4APDE4BPDE4DPDE4CPDE3B | |
| SCHEMBL9378730 | 0.81 | PDE4A (0.40) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL9376363 | 0.80 | SCN9A (0.36) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4637176 | 0.78 | PDE4B (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7361930 | 0.77 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4CPDE3B | |
| SCHEMBL4637250 | 0.76 | PDE4B (0.51) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7276559 | 0.74 | PDE4B (0.58) | PDE4APDE4BPDE4DPDE4CPDE3B | |
| SCHEMBL7276546 | 0.74 | PDE4B (0.58) | PDE4APDE4BPDE4DPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459145-A | Calcium independent camp phosphodiesterase inhibitor antidepressant | PFIZER INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |