Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.66 |
| ▸ | PDE4A | P27815 | 7/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360454 | 0.84 | PDE4A (0.67) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL9375254 | 0.84 | PDE4A (0.63) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL7362755 | 0.83 | PDE4A (0.60) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL7359713 | 0.83 | PDE4A (0.75) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL7362749 | 0.82 | PDE4A (0.56) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL6636364 | 0.82 | PDE4A (0.71) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL7361971 | 0.82 | PDE4A (0.60) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| SCHEMBL7363642 | 0.81 | PDE4A (0.87) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL31427010 | 0.80 | PDE4A (1.00) | PDE4DPDE4APDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL6637552 | 0.80 | PDE4A (1.00) | PDE4DPDE4APDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |