Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370144 | 0.86 | PDE4A (0.65) | PDE4APDE4DPDE4CPDE4BADRA1A | |
| SCHEMBL7361971 | 0.85 | PDE4A (0.60) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7360388 | 0.83 | PDE4D (0.66) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL6636364 | 0.80 | PDE4A (0.71) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL9375241 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7359713 | 0.80 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9375254 | 0.79 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7363642 | 0.76 | PDE4A (0.87) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7738892 | 0.75 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL8697092 | 0.75 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |