Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370135 | 0.85 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363890 | 0.85 | PDE4A (0.61) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7360386 | 0.85 | PDE4D (0.58) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9376027 | 0.83 | PDE4A (0.62) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9376018 | 0.81 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370079 | 0.79 | PDE4A (0.56) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7360454 | 0.77 | PDE4A (0.67) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370208 | 0.76 | PDE4A (0.53) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7361119 | 0.76 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9376021 | 0.76 | PDE4A (0.54) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |