Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375241 | 0.86 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CALDH1A1 | |
| SCHEMBL7370079 | 0.83 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7360445 | 0.81 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7363890 | 0.80 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7370135 | 0.79 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7370144 | 0.79 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL9376021 | 0.77 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL8308651 | 0.76 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL9378651 | 0.74 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL9376027 | 0.73 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |