Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359868 | 0.86 | KMT2A (0.43) | MAPTHPGDKMT2AALDH1A1POLB | |
| SCHEMBL70809 | 0.79 | PSMD14 (0.40) | PSMD14MAPK1ATMSMN1; SMN2RAB9A | |
| SCHEMBL71914 | 0.76 | KDM4E (0.50) | PSMD14MAPK1ATMSMN1; SMN2RAB9A | |
| SCHEMBL24529610 | 0.75 | MAPK1 (0.47) | PSMD14MAPK1ATMSMN1; SMN2RAB9A | |
| SCHEMBL72346 | 0.75 | KDM4E (0.46) | PSMD14MAPK1ATMSMN1; SMN2RAB9A | |
| SCHEMBL10297739 | 0.75 | MAPK1 (0.44) | PSMD14MAPK1ATMSMN1; SMN2RAB9A | |
| SCHEMBL70032 | 0.75 | PDE4B (0.42) | KMT2APDE4D | |
| SCHEMBL9680841 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL6865815 | 0.73 | CA12 (0.43) | SMN1; SMN2RAB9AMAPTL3MBTL1HSD17B10 | |
| SCHEMBL5150372 | 0.72 | KDM4E (0.62) | L3MBTL1KDM4EHPGDPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |