Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362625 | 0.93 | KCNH2 (0.46) | KCNH2KCNJ1KMT2AALDH1A1MAPK1 | |
| SCHEMBL7368439 | 0.87 | PDCD1 (0.40) | KDM4EPDCD1CD274PPARG | |
| SCHEMBL7363865 | 0.85 | KCNH2 (0.47) | KCNH2KCNJ1KMT2AALDH1A1CA12 | |
| SCHEMBL7363729 | 0.82 | KCNH2 (0.50) | KCNH2KCNJ1KMT2AALDH1A1CA12 | |
| SCHEMBL7359452 | 0.82 | PDCD1 (0.44) | KMT2ATDP1KDM4EPDCD1CD274 | |
| SCHEMBL7365136 | 0.81 | F2 (0.42) | KMT2AALDH1A1CA12CA1CA2 | |
| SCHEMBL8350250 | 0.80 | KCNH2 (0.46) | KCNH2KCNJ1KMT2AALDH1A1TDP1 | |
| SCHEMBL7361441 | 0.80 | FFAR1 (0.44) | KMT2ATDP1LMNAKDM4EMEN1 | |
| SCHEMBL7464051 | 0.79 | PDCD1 (0.42) | TDP1KDM4EPDCD1CD274PPARG | |
| SCHEMBL8345485 | 0.78 | KCNH2 (0.47) | KCNH2KCNJ1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |