Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.40 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363865 | 0.86 | KCNH2 (0.47) | KCNH2KCNJ1TSHRFFAR1MEN1 | |
| SCHEMBL7360601 | 0.82 | KCNH2 (0.44) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL8345485 | 0.82 | KCNH2 (0.47) | KCNH2KCNJ1TSHRFFAR1MEN1 | |
| SCHEMBL7365992 | 0.79 | KCNH2 (0.46) | KCNH2KCNJ1FFAR1ALDH1A1CA12 | |
| SCHEMBL7360603 | 0.77 | KCNH2 (0.45) | KCNH2KCNJ1FFAR1ALDH1A1CA12 | |
| SCHEMBL7462980 | 0.76 | KCNH2 (0.44) | KCNH2KCNJ1SLC22A2ADRB1SLC6A4 | |
| SCHEMBL2418609 | 0.76 | ALDH1A1 (0.54) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL7462970 | 0.76 | KCNH2 (0.43) | KCNH2KCNJ1SLC22A2ADRB1SLC6A4 | |
| SCHEMBL7457058 | 0.75 | KCNJ1 (0.54) | KCNH2KCNJ1TSHRMEN1KMT2A | |
| SCHEMBL8350250 | 0.74 | KCNH2 (0.46) | KCNH2KCNJ1FFAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |