⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661985 | 0.74 | — | — | |
| SCHEMBL25218973 | 0.74 | — | — | |
| SCHEMBL15646030 | 0.70 | — | — | |
| SCHEMBL11227180 | 0.70 | — | — | |
| SCHEMBL26483327 | 0.65 | — | — | |
| SCHEMBL24736462 | 0.62 | — | — | |
| SCHEMBL27977434 | 0.59 | ALDH1A1 (0.30) | — | |
| SCHEMBL20586 | 0.59 | — | — | |
| SCHEMBL3751552 | 0.59 | ALDH1A1 (0.30) | — | |
| SCHEMBL20212036 | 0.59 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025125665-A1 | FURTHER SUBSTITUTED IMIDAZOLES AS INHIBITORS OF NAV1.8 | Grünenthal GmbH (DE) | 2025-06-19 | — | — | WO | disclosed |
| EP-4263554-A1 | TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-10-25 | — | — | EP | disclosed |
| EP-4168413-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN Pharmaceutica NV (BE) | 2023-04-26 | — | — | EP | disclosed |
| WO-2023052593-A1 | RSV INHIBITING SPIRO BEARING DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2023-04-06 | — | — | WO | disclosed |
| EP-4157852-A1 | MACROCYCLIC 7-PYRAZOL-5-YL-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN Pharmaceutica NV (BE) | 2023-04-05 | — | — | EP | disclosed |
| EP-4107161-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | Janssen Pharmaceutica NV (BE) | 2022-12-28 | — | — | EP | disclosed |
| WO-2022136174-A1 | TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-30 | — | — | WO | disclosed |
| EP-3997097-A1 | MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2022-05-18 | — | — | EP | disclosed |
| EP-3986902-A1 | MACROCYCLIC INHIBITORS OF MCL-1 | Janssen Pharmaceutica NV (BE) | 2022-04-27 | — | — | EP | disclosed |
| CN-109071568-A | The preparation of difluoro chelating borate | 国轩高科美国研究院 | 2018-12-21 | — | — | CN | disclosed |
| US-5703106-A | TREATING VARIOUS CARDIOVASCULAR, UROGENITAL, BRAIN DISORDERS | JAPAT LTD. (CH) | 1997-12-30 | — | — | US | disclosed |
| WO-1997011960-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1997-04-03 | — | — | WO | disclosed |
| CN-1145075-A | Antagonist's of endothelin receptors | JAPAT LTD (CH) | 1997-03-12 | — | — | CN | disclosed |
| EP-0753004-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | Japat Ltd (CH) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026360-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1995-10-05 | — | — | WO | disclosed |