Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FCER2 | P06734 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSB | P07858 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6413367 | 0.87 | LMNA (0.40) | FCER2LMNAMMP9MMP8TACR1 | |
| SCHEMBL6417248 | 0.85 | MMP1 (0.41) | FCER2LMNAMMP9MMP8CTSL | |
| SCHEMBL6411770 | 0.84 | MMP1 (0.44) | FCER2LMNAMMP9MMP8CYP3A4 | |
| SCHEMBL7363465 | 0.84 | LMNA (0.37) | FCER2LMNAMMP9MMP8TACR1 | |
| SCHEMBL7364461 | 0.82 | FCER2 (0.47) | FCER2MMP9MMP8MMP1MMP2 | |
| SCHEMBL6420230 | 0.79 | LMNA (0.41) | LMNAMMP9MMP8CYP3A4MMP1 | |
| SCHEMBL6414511 | 0.71 | FCER2 (0.44) | FCER2MMP1MMP2 | |
| SCHEMBL7430536 | 0.69 | MMP1 (0.46) | FCER2MMP9MMP8MMP1MMP2 | |
| SCHEMBL7361142 | 0.68 | FCER2 (0.46) | FCER2MMP9MMP8MMP1MMP2 | |
| SCHEMBL7365448 | 0.68 | MMP1 (0.55) | FCER2MMP9MMP8MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691382-A | ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |