Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360699 | 1.00 | LMNA (0.49) | LMNAMAPTNPSR1HCAR2KLK7 | |
| SCHEMBL22500165 | 0.79 | ALDH1A1 (0.51) | LMNAMAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL22500167 | 0.79 | ALDH1A1 (0.51) | LMNAMAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL22505223 | 0.78 | MAPT (0.56) | LMNAMAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL28688374 | 0.78 | MAPT (0.56) | LMNAMAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL8182843 | 0.78 | AKR1C3 (0.52) | LMNAMAPTNPSR1HCAR2ALDH1A1 | |
| SCHEMBL1930557 | 0.78 | AKR1C3 (0.52) | LMNAMAPTNPSR1HCAR2ALDH1A1 | |
| SCHEMBL28678389 | 0.77 | MAPT (0.51) | LMNAMAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL24534706 | 0.75 | ALDH1A1 (0.53) | LMNAMAPTKLK7KLK5ALDH1A1 | |
| SCHEMBL28677401 | 0.75 | ALDH1A1 (0.53) | LMNAMAPTKLK7KLK5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746320-B1 | HIV PROTEASE INHIBITORS AND INTERMEDIATES | LILLY CO ELI (US) | 2001-01-31 | — | — | EP | disclosed |
| EP-0746320-A4 | HIV PROTEASE INHIBITORS AND INTERMEDIATES | LILLY CO ELI (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0744948-A4 | PROTEASE INHIBITORS | LILLY CO ELI (US) | 1997-06-11 | — | — | EP | disclosed |
| US-5624934-A | PREVENTING HIV INFECTION | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0746320-A1 | HIV PROTEASE INHIBITORS AND INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0744948-A1 | PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5480887-A | FOR HIV, THIENO(3,2-C)PYRIDINE-(6S)-CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| WO-1995020962-A1 | PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1995-08-10 | — | — | WO | disclosed |
| WO-1995020965-A1 | HIV PROTEASE INHIBITORS AND INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1995-08-10 | — | — | WO | disclosed |