SCHEMBL7360727

SCHEMBL7360727

O=C1c2ccc(F)cc2C(=O)N1c1cccc(O)c1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 7/20 0.77
NPC1 O15118 1/20 0.69
RAB9A P51151 1/20 0.69
MEN1 O00255 2/20 0.57
ALDH1A1 P00352 2/20 0.57
KMT2A Q03164 2/20 0.57
MAPT P10636 1/20 0.57
POLB P06746 2/20 0.57
KDM4E B2RXH2 1/20 0.57
ESR2 Q92731 4/20 0.54
USP2 O75604 1/20 0.49
TNNI3 P19429 1/20 0.49
HTT P42858 1/20 0.49
TNNT2 P45379 1/20 0.49
TNNC1 P63316 1/20 0.49
TLR9 Q9NR96 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
CTDSP1 Q9GZU7 1/20 0.48
ANPEP P15144 2/20 0.48
DPP4 P27487 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1735146 0.89 ESR1 (0.57) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL9588495 0.87 ESR1 (1.00) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL7392605 0.85 ESR1 (0.54) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL759648 0.84 ESR1 (0.81) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL1662738 0.83 ESR1 (0.80) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL17326723 0.83 KDM4E (0.57) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL31012107 0.82 ESR1 (0.90) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL3477804 0.82 ESR1 (0.64) ESR1MEN1ALDH1A1KMT2AMAPT
SCHEMBL9630819 0.82 ESR1 (0.90) ESR1NPC1RAB9AMEN1ALDH1A1
SCHEMBL16521526 0.82 NPC1 (1.00) ESR1NPC1RAB9AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1179026-A4 BRANCHED AND HYPERBRANCHED POLYETHERIMIDES FROM STABLE A1Bn, AB, AA, AND BB MONOMERS; AM ENDCAPPING AGENTS UNIV ILLINOIS (US) 2003-04-02 EP disclosed
EP-1179026-A1 BRANCHED AND HYPERBRANCHED POLYETHERIMIDES FROM STABLE A1Bn, AB, AA, AND BB MONOMERS; AM ENDCAPPING AGENTS The Board of Trustees for the University of Illinois (US) 2002-02-13 EP disclosed
US-6333390-B1 HIGH SOLUBILITY AND LOW VISCOSITY, THERMALLY AND CHEMICALLY STABLE, REACTING AN AMINO-PHENOL WITH AN AROMATIC ANHYDRIDE, MIXING THE RESULTING ARYLIMIDE WITH A SILYL ELECTROPHILE AND A BASE, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2001-12-25 US disclosed
WO-2000026267-A9 BRANCHED AND HYPERBRANCHED POLYETHERIMIDES FROM STABLE A1Bn, AB, AA, AND BB MONOMERS; AM ENDCAPPING AGENTS UNIV ILLINOIS (US) 2000-10-19 WO disclosed
WO-2000026267-A1 BRANCHED AND HYPERBRANCHED POLYETHERIMIDES FROM STABLE A1Bn, AB, AA, AND BB MONOMERS; AM ENDCAPPING AGENTS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2000-05-11 WO disclosed