SCHEMBL1735146

SCHEMBL1735146

O=C1c2ccc(F)cc2C(=O)N1c1cccc(N2C(=O)c3ccc(F)cc3C2=O)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.57
FAAH O00519 2/20 0.50
MGLL Q99685 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
POLB P06746 1/20 0.50
CTDSP1 Q9GZU7 1/20 0.50
NR1H3 Q13133 1/20 0.47
AR P10275 2/20 0.47
PGR P06401 1/20 0.47
SCN2A Q99250 1/20 0.46
MAPK1 P28482 1/20 0.44
ESR2 Q92731 1/20 0.44
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17326723 0.90 KDM4E (0.57) ESR1FAAHMGLLNPC1RAB9A
SCHEMBL3477804 0.89 ESR1 (0.64) ESR1POLBCTDSP1NR1H3AR
SCHEMBL7360727 0.89 ESR1 (0.77) ESR1NPC1RAB9APOLBCTDSP1
SCHEMBL17326263 0.89 MAPK1 (0.59) ESR1MGLLNPC1RAB9AAR
SCHEMBL1734116 0.86 ESR1 (0.58) ESR1MGLLNPC1RAB9APOLB
SCHEMBL17326658 0.86 MGLL (0.54) ESR1MGLLNR1H3ARALDH1A1
SCHEMBL17326262 0.85 KMT2A (0.60) RAB9APOLBCTDSP1MAPK1ALDH1A1
SCHEMBL7400864 0.83 PGR (0.63) ESR1FAAHMGLLPOLBCTDSP1
SCHEMBL13265371 0.80 ALDH1A1 (0.65) ESR1NPC1RAB9APOLBAR
SCHEMBL725608 0.80 NR1H3 (0.67) ESR1FAAHMGLLNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2162457-B1 CARBAZOLYL POLYMERS FOR ORGANIC ELECTRONIC DEVICES BOE TECHNOLOGY GROUP CO LTD (CN) 2018-08-22 EP disclosed
EP-2102160-B1 CARBAZOLYL MONOMERS AND POLYMERS GEN ELECTRIC (US) 2011-11-16 EP disclosed
US-20110262920-A1 METHODS FOR PREDICTING SURVIVAL IN CANCER PATIENTS CITY OF HOPE 2011-10-27 US disclosed
EP-2102159-B1 BIS-CARBAZOLE MONOMERS AND POLYMERS GEN ELECTRIC (US) 2011-06-22 EP disclosed
US-7851579-B2 Monomers comprising carbazole units and polymers, dendrimers, and hyper-branched materials derived therefrom; OLEDs having device quantum efficiencies, while still maintaining the potential for the molecules to host red, green, and blue emissive complexes GENERAL ELECTRIC COMPANY (US) 2010-12-14 US disclosed
EP-2162457-A2 CARBAZOLYL POLYMERS FOR ORGANIC ELECTRONIC DEVICES General Electric Company (US) 2010-03-17 EP disclosed
US-7635777-B2 Carbazolyl monomers and polymers GENERAL ELECTRIC COMPANY (US) 2009-12-22 US disclosed
EP-2102160-A1 CARBAZOLYL MONOMERS AND POLYMERS GENERAL ELECTRIC COMPANY (US) 2009-09-23 EP disclosed
EP-2102159-A1 BIS-CARBAZOLE MONOMERS AND POLYMERS GENERAL ELECTRIC COMPANY (US) 2009-09-23 EP disclosed
WO-2009023335-A2 CARBAZOLYL POLYMERS FOR ORGANIC ELECTRONIC DEVICES GENERAL ELECTRIC COMPANY (US) 2009-02-19 WO disclosed
WO-2008076569-A1 BIS-CARBAZOLE MONOMERS AND POLYMERS GENERAL ELECTRIC COMPANY (US) 2008-06-26 WO disclosed
WO-2008073694-A1 CARBAZOLYL MONOMERS AND POLYMERS GENERAL ELECTRIC COMPANY (US) 2008-06-19 WO disclosed
US-20080145665-A1 polyesters, polyethers, polycarbonates, polyestercarbonates, polyetherketones, or polyethersulfones for use in organic light emitters; quantum efficiencies GENERAL ELECTRIC COMPANY (US) 2008-06-19 US disclosed
US-20080138625-A1 CARBAZOLYL MONOMERS AND POLYMERS GENERAL ELECTRIC COMPANY (US) 2008-06-12 US disclosed
US-20080135806-A1 CARBAZOLYL POLYMERS FOR ORGANIC ELECTRONIC DEVICES GENERAL ELECTRIC COMPANY (US) 2008-06-12 US disclosed
US-7381985-B1 Bis-carbazole monomers and polymers GENERAL ELECTRIC COMPANY (US) 2008-06-03 US disclosed
EP-0816414-A2 Preparation of polyether polymers GENERAL ELECTRIC COMPANY (US) 1998-01-07 EP disclosed
US-5663275-A POLYETHERIMIDES, HIGH MOLECULAR WEIGHT, ENGINEERING RESINS GENERAL ELECTRIC COMPANY (US) 1997-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080138625-A1 CARBAZOLYL MONOMERS AND POLYMERS CBR3, C1S, C3AR1 ESR1 1884/4885FAAH 1617/4885MGLL 3311/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.