Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360743 | 1.00 | KMT2A (0.36) | KMT2AESR1ESR2MAPTELANE | |
| SCHEMBL8667176 | 0.80 | ESR1 (0.34) | ESR1ESR2ELANEALDH1A1KDM4E | |
| SCHEMBL9460459 | 0.80 | ELANE (0.43) | ESR1ESR2ELANEALDH1A1KDM4E | |
| SCHEMBL8668726 | 0.80 | ELANE (0.43) | ESR1ESR2ELANEALDH1A1KDM4E | |
| SCHEMBL8667178 | 0.80 | ESR1 (0.34) | ESR1ESR2ELANEALDH1A1KDM4E | |
| SCHEMBL9635856 | 0.77 | ELANE (0.45) | KMT2AESR1ESR2MAPTELANE | |
| SCHEMBL8668638 | 0.73 | KMT2A (0.36) | KMT2AESR1ESR2ELANEALDH1A1 | |
| SCHEMBL11075343 | 0.71 | KMT2A (0.34) | KMT2AESR1ESR2MAPTELANE | |
| SCHEMBL11083750 | 0.70 | ALDH1A1 (0.43) | KMT2AESR1ESR2MAPTELANE | |
| SCHEMBL11083737 | 0.70 | ALDH1A1 (0.43) | KMT2AESR1ESR2MAPTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733055-A1 | 2-SPIRO(2'-SPIROCYCLOALKYL)CYCLOPROPYL CEPHALOSPORIN SULFONES AS ANTIINFLAMMATORY AND ANTIDEGENERATIVE AGENTS | SYNPHAR LABORATORIES INC. (CA) | 1996-09-25 | — | — | EP | disclosed |
| US-5439904-A | Enzyme inhibitors of human leukocyte elastase; respiratory system disorders; antiarthritic agents | SYNPHAR LABORATORIES, INC. (CA) | 1995-08-08 | — | — | US | disclosed |
| WO-1995015966-A1 | 2-SPIRO(2'-SPIROCYCLOALKYL)CYCLOPROPYL CEPHALOSPORIN SULFONES AS ANTIINFLAMMATORY AND ANTIDEGENERATIVE AGENTS | SYNPHAR LABORATORIES, INC. (CA) | 1995-06-15 | — | — | WO | disclosed |
| US-5264430-A | Enzyme inhibitor, antiinflammatory agents, treats emphysema, cystic fibrosis and arthritis | SYNPHAR LABORATORIES, INC. (CA) | 1993-11-23 | — | — | US | disclosed |
| US-5264429-A | Enzyme inhibitor, antiinflammatory agents, treats emphysema, cystic fibrosis and arthritis | SYNPHAR LABORATORIES, INC. (CA) | 1993-11-23 | — | — | US | disclosed |