Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PARG | Q86W56 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486671 | 0.89 | ROCK2 (0.49) | C5AR1PIK3R1PIK3CAROCK2BRD4 | |
| SCHEMBL8438703 | 0.87 | C5AR1 (0.49) | C5AR1PIK3R1PIK3CAPARGALDH1A1 | |
| SCHEMBL8443423 | 0.85 | CFTR (0.52) | ROCK2BRD4PARGGRIN1GRIN2B | |
| SCHEMBL7359317 | 0.83 | KLKB1 (0.51) | PIK3R1PIK3CAROCK2BRD4PARG | |
| SCHEMBL8438698 | 0.79 | CCR2 (0.50) | PIK3R1PIK3CAROCK2BRD4PARG | |
| SCHEMBL8443463 | 0.79 | CCR2 (0.53) | PIK3R1PIK3CAROCK2BRD4PARG | |
| SCHEMBL8487543 | 0.77 | CFTR (0.54) | ROCK2BRD4GRIN1GRIN2BCCR2 | |
| SCHEMBL8487078 | 0.77 | ROCK2 (0.46) | PIK3R1PIK3CAROCK2BRD4PARG | |
| SCHEMBL8483528 | 0.76 | GLA (0.50) | PIK3R1PIK3CAROCK2BRD4PARG | |
| SCHEMBL8439957 | 0.76 | CFTR (0.58) | ROCK2GRIN1GRIN2BCCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863914-A | ADMINISTERING TO HUMAN N,N-DIMETHYLBENZENE OR N,N-DIMETHYLNAPHTHALENE-CYCLIC UREA DERIVATIVE TO TREAT A DISEASE-STATE CAUSED BY INHIBITION OF FACTOR XA | MOHAN RAJU (US) | 1999-01-26 | — | — | US | disclosed |
| US-5859005-A | INHIBITORS OF THROMBIN AND FACTOR XA | BERLEX LABORATORIES, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0848708-A1 | N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5731308-A | N,N-di(aryl) cyclic urea derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5731311-A | N,N-di(aryl) cyclic urea derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5726173-A | ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5726198-A | FOR INHIBITING COAGULATION ENZYMES | BERLEX LABORATORIES, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5612363-A | FACTOR XA INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996038421-A1 | N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS | BERLEX LABORATORIES, INC. (US) | 1996-12-05 | — | — | WO | disclosed |