Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9540264 | 0.80 | KCNH2 (0.43) | KCNH2HTR4HTR7RAB9AKDM4E | |
| SCHEMBL6946844 | 0.75 | KCNH2 (0.45) | KCNH2HTR7RAB9AKDM4EALDH1A1 | |
| SCHEMBL9340442 | 0.75 | KDM4E (0.45) | KCNH2RAB9AKDM4EALDH1A1PMP22 | |
| Hydrochloric Acid SCHEMBL9344904 | 0.72 | KDM4E (0.43) | KCNH2KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL9341470 | 0.72 | HTR4 (0.50) | KCNH2HTR4HTR7KDM4EALDH1A1 | |
| SCHEMBL7383392 | 0.70 | KCNH2 (0.51) | KCNH2HTR7KDM4E | |
| SCHEMBL9342316 | 0.70 | HTR4 (0.48) | KCNH2HTR4HTR7KDM4EALDH1A1 | |
| SCHEMBL7357788 | 0.70 | HTR7 (0.55) | KCNH2HTR4HTR7RAB9A | |
| SCHEMBL7348366 | 0.69 | KCNH2 (0.46) | KCNH2HTR4RAB9A | |
| SCHEMBL7346874 | 0.69 | KCNH2 (0.46) | KCNH2HTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630376-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT 4?-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018036-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-09-16 | — | — | WO | disclosed |