Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361181 | 0.93 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7352753 | 0.88 | PDE5A (0.48) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL7361371 | 0.87 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7359488 | 0.86 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL15595474 | 0.83 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7427328 | 0.83 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7362627 | 0.80 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7354110 | 0.79 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7355219 | 0.79 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7359015 | 0.78 | PDE4B (0.44) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |