Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899988 | 0.93 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL3795836 | 0.93 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL20817334 | 0.93 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL23929990 | 0.92 | HPGD (0.53) | HPGDPDE5AVCAM1ARPELP1 | |
| SCHEMBL30138067 | 0.92 | HPGD (0.53) | HPGDPDE5AVCAM1ARPELP1 | |
| SCHEMBL7358125 | 0.90 | PDE5A (0.57) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL29189681 | 0.89 | VCAM1 (0.48) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL15595474 | 0.82 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL17101115 | 0.82 | ALDH1A1 (0.56) | HPGDPDE5AVCAM1ALDH1A1KMT2A | |
| SCHEMBL7427328 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |