Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.53 |
| ▸ | PDE4A | P27815 | 9/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704079 | 0.90 | NOTUM (0.54) | PDE4DPDE4APDE4BPDE4CNOTUM | |
| SCHEMBL30117191 | 0.90 | NOTUM (0.54) | PDE4DPDE4APDE4BPDE4CNOTUM | |
| SCHEMBL15595474 | 0.86 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361375 | 0.86 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL72571 | 0.84 | NOTUM (0.48) | PDE4DPDE4APDE4BPDE4CNOTUM | |
| SCHEMBL7360845 | 0.83 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| Hydrochloric Acid SCHEMBL72570 | 0.83 | NOTUM (0.47) | PDE4DPDE4APDE4BPDE4CNOTUM | |
| SCHEMBL7355219 | 0.82 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL30915196 | 0.80 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CALOX15 | |
| SCHEMBL2587167 | 0.79 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |