SCHEMBL7360946

SCHEMBL7360946

O=C=CCc1ccncc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
ALDH1A1 P00352 2/20 0.44
HSD17B10 Q99714 1/20 0.44
LOXL2 Q9Y4K0 2/20 0.41
FDPS P14324 1/20 0.34
POLB P06746 1/20 0.34
HRH1 P35367 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
HDAC6 Q9UBN7 2/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
ALPL P05186 1/20 0.33
ALPI P09923 1/20 0.33
ALPG P10696 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57808 0.76 MAOB (0.52) CYP1A2LOXL2
SCHEMBL272745 0.75
SCHEMBL2318680 0.75 NAPRT (0.47) CYP1A2CYP3A4CYP2D6CYP2C9FDPS
Bromide SCHEMBL9249645 0.73 CYP3A4 (0.50) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1387883 0.73 ESR1 (0.44) CYP2C19ALDH1A1TDP1
SCHEMBL7569322 0.73 IDO1 (0.41) CYP1A2ALDH1A1TDP1
SCHEMBL5699094 0.73 TRPA1 (0.42) LOXL2SMN1; SMN2
SCHEMBL15855844 0.72 IDO1 (0.46) ALDH1A1
SCHEMBL5495225 0.72 CYP3A4 (0.55) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL6599690 0.71 CYP2A6 (0.39) CYP3A4ALDH1A1HSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0989973-A1 CHALCONES HAVING ANTIPROLIFERATIVE ACTIVITY INDENA S.p.A. (IT) 2000-04-05 EP disclosed
WO-1998058913-A1 CHALCONES HAVING ANTIPROLIFERATIVE ACTIVITY INDENA S.P.A. (IT) 1998-12-30 WO disclosed
EP-0700383-B1 NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS SYNTEX INC (US) 1998-09-23 EP disclosed
US-5763458-A NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS SYNTEX (U.S.A.) INC. (US) 1998-06-09 US disclosed
EP-0700383-A1 NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS SYNTEX (U.S.A.) INC. (US) 1996-03-13 EP disclosed
WO-1994027965-A1 NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS SYNTEX (U.S.A.) INC. (US) 1994-12-08 WO disclosed