Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.44 |
| ▸ | METAP1 | P53582 | 8/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357037 | 1.00 | METAP2 (0.44) | METAP2METAP1POLBRENCTSS | |
| SCHEMBL7357465 | 0.80 | METAP2 (0.47) | METAP2METAP1DPP4 | |
| SCHEMBL7352932 | 0.80 | METAP2 (0.47) | METAP2METAP1DPP4 | |
| SCHEMBL7558136 | 0.80 | METAP2 (0.47) | METAP2METAP1DPP4 | |
| SCHEMBL10408952 | 0.73 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL8910737 | 0.71 | METAP2 (0.54) | METAP2METAP1REN | |
| SCHEMBL5848395 | 0.71 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL5848443 | 0.71 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL7761788 | 0.71 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL10420791 | 0.71 | METAP2 (0.56) | METAP2METAP1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |