Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.54 |
| ▸ | METAP1 | P53582 | 8/20 | 0.50 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10408952 | 0.84 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL5848395 | 0.81 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL10420791 | 0.81 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL5848443 | 0.81 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL6261330 | 0.81 | METAP2 (0.56) | METAP2METAP1REN | |
| SCHEMBL7761788 | 0.81 | METAP2 (0.56) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL9373224 | 0.80 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL7328407 | 0.79 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL8175196 | 0.79 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL9514512 | 0.79 | METAP2 (0.62) | METAP2METAP1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |