Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548755 | 0.89 | NAPRT (0.51) | NAPRTKDM4EMAPTCTNNB1WNT3A | |
| SCHEMBL7371695 | 0.84 | NAPRT (0.61) | NAPRTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7367839 | 0.82 | NAPRT (0.44) | NAPRTDAGLACTNNB1WNT3ACYP19A1 | |
| SCHEMBL557803 | 0.78 | RAB9A (0.67) | NAPRTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7355212 | 0.77 | DHODH (0.66) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7369624 | 0.77 | KMT2A (0.57) | ALDH1A1KMT2ATDP1 | |
| SCHEMBL7455572 | 0.76 | NAPRT (0.63) | NAPRTSMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL7679848 | 0.75 | NAPRT (0.57) | NAPRTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3962348 | 0.75 | NAPRT (0.61) | NAPRTSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL2409306 | 0.75 | NAPRT (0.61) | NAPRTSMN1; SMN2NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104420-B1 | SUBSTITUTED 1,8-NAPHTHYRIDIN-4(1H)-ONES AS PHOSPHODIESTERASE 4 INHIBITORS | PFIZER PROD INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-1104420-A1 | SUBSTITUTED 1,8-NAPHTHYRIDIN-4(1H)-ONES AS PHOSPHODIESTERASE 4 INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| US-6174895-B1 | USEFUL IN TREATMENT OF RESPIRATORY, ALLERGIC, RHEUMATOID, BODY WEIGHT REGULATION, INFLAMMATORY AND CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ADULT RESPIRATORY DISEASES SYNDROME, FIBROSIS | PFIZER INC. | 2001-01-16 | — | — | US | disclosed |
| WO-2000009504-A1 | SUBSTITUTED 1,8-NAPHTHYRIDIN-4(1H)-ONES AS PHOSPHODIESTERASE 4 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |