Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357352 | 0.91 | PDE4B (0.53) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7359135 | 0.90 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL9287915 | 0.89 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL27537534 | 0.89 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7395197 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL8573504 | 0.85 | PDE4A (0.58) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL11001026 | 0.85 | ALDH1A1 (0.52) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7099179 | 0.83 | PDE4B (0.53) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7363845 | 0.81 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7913418 | 0.81 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |