Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366317 | 0.91 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL2988958 | 0.86 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7363752 | 0.85 | GAA (0.59) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL4637255 | 0.85 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4CPOLB | |
| Hydrochloric Acid SCHEMBL4638650 | 0.85 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7442504 | 0.85 | PDE4A (0.57) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL3181116 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4822203 | 0.82 | PDE4A (0.68) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7371994 | 0.81 | PDE4B (0.54) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL8357145 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |