Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SAT1 | P21673 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362726 | 0.91 | CYP2C19 (0.35) | MEN1KMT2ACYP2C19GLACYP1A2 | |
| SCHEMBL7366275 | 0.86 | MEN1 (0.35) | MEN1KMT2ACYP2C19GAACYP2C9 | |
| SCHEMBL3972281 | 0.84 | CYP2C19 (0.43) | MEN1KMT2ACYP2C19GAACYP2C9 | |
| SCHEMBL9079152 | 0.82 | CYP2C19 (0.41) | MEN1KMT2ACYP2C19GAACYP2C9 | |
| SCHEMBL2760168 | 0.82 | KMT2A (0.41) | MEN1KMT2ACYP2C19CYP2C9POLB | |
| SCHEMBL3318180 | 0.81 | PRMT3 (0.37) | MEN1KMT2ACYP2C19GAACYP2C9 | |
| SCHEMBL4192702 | 0.80 | CYP2C19 (0.39) | MEN1KMT2ACYP2C19GLACYP1A2 | |
| SCHEMBL250410 | 0.79 | CYP2C19 (0.43) | MEN1KMT2ACYP2C19GLACYP1A2 | |
| SCHEMBL3318173 | 0.79 | ADH1B (0.40) | MEN1KMT2ACYP2C19GAACYP2C9 | |
| SCHEMBL2866446 | 0.78 | MEN1 (0.38) | MEN1KMT2ACYP2C19GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5348953-A | Elastase inhibitor | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| WO-1994013636-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-06-23 | — | — | WO | disclosed |
| EP-0525973-A2 | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1993000332-A1 | SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1993-01-07 | — | — | WO | disclosed |