Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.51 |
| ▸ | POLQ | O75417 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357361 | 0.89 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CPOLQ | |
| SCHEMBL7358102 | 0.84 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CPOLQ | |
| SCHEMBL7362064 | 0.83 | GRM5 (0.45) | PDE4DPDE4APDE4BPDE4CPOLQ | |
| SCHEMBL7356755 | 0.81 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6606335 | 0.80 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6606836 | 0.79 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7352658 | 0.79 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361578 | 0.79 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7352652 | 0.79 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7152154 | 0.79 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |