Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4A | P27815 | 7/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73312 | 0.82 | PDE4B (0.46) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7357361 | 0.80 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7361106 | 0.79 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6606335 | 0.78 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CERBB2 | |
| SCHEMBL6606836 | 0.77 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CERBB2 | |
| SCHEMBL498305 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL497696 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL497697 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6609841 | 0.75 | PDE4B (0.47) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1223854 | 0.75 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1068194-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999050262-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-10-07 | — | — | WO | disclosed |