Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482468 | 0.87 | CLK4 (0.58) | SMN1; SMN2MAPTKDM4EALDH1A1CLK4 | |
| SCHEMBL7364847 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL4699130 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL3162758 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL11158624 | 0.78 | MAPT (0.59) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL3160984 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL11162191 | 0.78 | KDM4E (0.65) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL3172246 | 0.77 | KDM4E (0.65) | KDM4EBRAFCYP17A1 | |
| Hydrochloric Acid SCHEMBL11366478 | 0.77 | KDM4E (0.64) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL11167079 | 0.76 | MAP2K1 (0.59) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| EP-0025819-B1 | SUBSTITUTED PYRAZOLO (1,5-A) PYRIMIDINES, AND THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1983-10-12 | — | — | EP | disclosed |
| US-4281000-A | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents | AMERICAN CYANAMID COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0025819-A1 | Substituted pyrazolo (1,5-a) pyrimidines, and their preparation | AMERICAN CYANAMID COMPANY (US) | 1981-04-01 | — | — | EP | disclosed |