Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482468 | 0.88 | CLK4 (0.58) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL7361403 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL4702080 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL11350246 | 0.76 | NPC1 (0.67) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL3172246 | 0.75 | KDM4E (0.65) | KDM4E | |
| SCHEMBL29935834 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL14264668 | 0.74 | MAPT (0.36) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL14264667 | 0.74 | KDM4E (0.36) | ALDH1A1NPC1RAB9AKDM4ECLK4 | |
| SCHEMBL9868803 | 0.74 | MAP2K1 (0.80) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL11346886 | 0.73 | KDM4E (0.78) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |