Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361542 | 0.78 | HTT (0.34) | P2RX7HTT | |
| SCHEMBL7361539 | 0.78 | HTT (0.34) | P2RX7HTT | |
| SCHEMBL7357922 | 0.75 | P2RX7 (0.51) | P2RX7KCNJ11 | |
| SCHEMBL8622511 | 0.74 | P2RX7 (0.69) | P2RX7HTTKCNJ11 | |
| SCHEMBL7357699 | 0.74 | P2RX7 (0.35) | P2RX7KCNJ11 | |
| SCHEMBL7358026 | 0.72 | P2RX7 (0.41) | P2RX7KCNJ11 | |
| SCHEMBL7359977 | 0.69 | P2RX7 (0.39) | P2RX7KCNJ11 | |
| SCHEMBL7362660 | 0.69 | P2RX7 (0.41) | P2RX7KCNJ11 | |
| SCHEMBL7363333 | 0.69 | MAPKAPK2 (0.40) | P2RX7KCNJ11 | |
| SCHEMBL7354769 | 0.67 | P2RX7 (0.38) | P2RX7KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | disclosed |