Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | QPCT | Q16769 | 2/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358026 | 0.82 | P2RX7 (0.41) | P2RX7KCNJ11MAPKAPK2NAMPTQPCT | |
| SCHEMBL8619031 | 0.79 | HDAC3 (0.33) | DGAT1NAMPTHDAC1APP | |
| SCHEMBL7354766 | 0.79 | HDAC3 (0.33) | DGAT1NAMPTHDAC1APP | |
| SCHEMBL7357922 | 0.77 | P2RX7 (0.51) | P2RX7KCNJ11NAMPTABCC9MEN1 | |
| SCHEMBL8620026 | 0.76 | HRH4 (0.50) | P2RX7NAMPTQPCT | |
| SCHEMBL8619795 | 0.75 | KCNJ11 (0.41) | P2RX7KCNJ11DGAT1QPCTABCC9 | |
| SCHEMBL7363333 | 0.74 | MAPKAPK2 (0.40) | P2RX7KCNJ11MAPKAPK2ABCC9 | |
| SCHEMBL8623172 | 0.73 | MEN1 (0.31) | DGAT1MEN1KMT2A | |
| SCHEMBL7362660 | 0.73 | P2RX7 (0.41) | P2RX7KCNJ11MAPKAPK2NAMPTQPCT | |
| SCHEMBL7359977 | 0.71 | P2RX7 (0.39) | P2RX7KCNJ11NAMPTABCC9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |