Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | F10 | P00742 | 4/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364254 | 0.85 | MMP12 (0.47) | MMP12MMP13F10FFAR1FFAR4 | |
| SCHEMBL7361040 | 0.85 | F10 (0.58) | MMP12MMP13F10F2PRSS1 | |
| SCHEMBL7361941 | 0.85 | F10 (0.58) | MMP12MMP13F10FFAR1FFAR4 | |
| SCHEMBL7366873 | 0.84 | ABCB1 (0.50) | MMP12MMP13F10FFAR1FFAR4 | |
| SCHEMBL7362399 | 0.83 | MMP12 (0.43) | MMP12MMP13F10FFAR1F2 | |
| Benzonitrile SCHEMBL7358669 | 0.80 | FFAR1 (0.49) | MMP12MMP13FFAR1FNTAFNTB | |
| SCHEMBL7364249 | 0.80 | F2 (0.62) | MMP12MMP13F10CNR1CNR2 | |
| SCHEMBL7357512 | 0.79 | FFAR1 (0.46) | MMP12MMP13FFAR1FNTAFNTB | |
| SCHEMBL7362516 | 0.78 | F10 (0.67) | MMP12MMP13F10F2PRSS1 | |
| SCHEMBL7363315 | 0.77 | F10 (0.60) | F10FFAR1FFAR4F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5942544-A | α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |