Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.52 |
| ▸ | ANPEP | P15144 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LAP3 | P28838 | 3/20 | 0.50 |
| ▸ | CPA3 | P15088 | 3/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.50 |
| ▸ | CPB1 | P15086 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361969 | 1.00 | CYP1A2 (0.56) | CYP1A2ERAP2ANPEPMAPTMAPK1 | |
| SCHEMBL7361690 | 1.00 | CYP1A2 (0.56) | CYP1A2ERAP2ANPEPMAPTMAPK1 | |
| SCHEMBL10793791 | 0.92 | MME (0.47) | CYP1A2ANPEPMAPTMAPK1PPARG | |
| SCHEMBL7362615 | 0.92 | MME (0.47) | CYP1A2ANPEPMAPTMAPK1PPARG | |
| SCHEMBL7362616 | 0.92 | MME (0.47) | CYP1A2ANPEPMAPTMAPK1PPARG | |
| SCHEMBL10389858 | 0.90 | EPHX2 (0.54) | CYP1A2MAPTMAPK1PPARG | |
| SCHEMBL9068547 | 0.87 | CYP1A2 (0.54) | CYP1A2ERAP2ANPEPLAP3CPA3 | |
| SCHEMBL10784401 | 0.84 | CYP1A2 (0.51) | CYP1A2ERAP2ANPEPLAP3CPA3 | |
| SCHEMBL10796331 | 0.82 | EPHX2 (0.50) | ANPEPMAPTMAPK1PPARG | |
| SCHEMBL10796336 | 0.82 | EPHX2 (0.50) | ANPEPMAPTMAPK1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0184550-B1 | 5-AMINO-4-HYDROXY VALERYL AMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-03-18 | — | — | EP | disclosed |
| US-5055466-A | Renin inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4931591-A | Novel 5-amino-4-hydroxyvaleryl derivatives | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |
| US-4423242-A | HYPOTENSIVES, ENKEPHALINASE INHIBITORS | THE WELLCOME FOUNDATION LTD. (GB) | 1983-12-27 | — | — | US | disclosed |
| EP-0075334-A2 | Pharmaceutical compounds, and preparation, formulations and use thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-03-30 | — | — | EP | disclosed |